The flight from Buenos Aires Ezeiza to Santiago is one of South America's most iconic short-haul routes, connecting two of the continent's most vibrant capitals in just under two hours. What makes this journey particularly memorable is the dramatic crossing over the Andes Mountains. If the skies are clear and you've secured a window seat on the left side of the aircraft heading westbound, you'll be treated to staggering views of snow-capped peaks, including glimpses of Aconcagua, the tallest mountain in the Western Hemisphere.
Several major carriers operate flights from EZE to SCL throughout the day, giving travelers plenty of flexibility. Aerolíneas Argentinas, LATAM Airlines, JetSmart, and Sky Airline all serve this corridor, with frequency often exceeding a dozen daily departures. The competition between full-service and low-cost carriers means there's a range of options depending on whether you prioritize legroom and meals or a lighter fare. Booking a few weeks in advance typically yields the most reasonable prices, though last-minute availability is rarely an issue given the volume of service.
Santiago welcomes visitors year-round, but the best time to travel depends on what you're after. The Chilean capital enjoys a Mediterranean climate, with warm, dry summers from December through February that are perfect for exploring the city's parks, rooftop bars, and nearby wine country. If skiing in the Andes is on your agenda, June through August transforms the mountains flanking Santiago into a winter sports playground, with resorts like Valle Nevado and Portillo within easy reach. Spring months of September and October bring pleasant temperatures and blooming landscapes without the summer crowds.
At Ezeiza, international departures can involve longer security and immigration queues, so arriving at least two and a half hours before your flight is wise. Chilean customs are notably strict about bringing in fresh produce, dairy, and meat products, so finish any Argentine empanadas before landing. Santiago's Arturo Merino Benítez Airport is well connected to the city center via bus services, taxis, and ride-hailing apps.
This route appeals to business travelers, weekend adventurers, and backpackers alike. Many passengers use it as a starting point for broader South American itineraries, combining the cosmopolitan energy of Buenos Aires with Santiago's unique blend of urban sophistication and mountain proximity. Whether you're drawn by the gastronomy, the wine regions, or simply the thrill of hopping between two great cities separated by the world's longest continental mountain range, flying from Buenos Aires to Santiago delivers an experience that punches well above its brief flight time.